Venegas' breakthrough came in 2003 with the song "Andar Conmigo", from the album Sí, which reached number-one in the Mexican Singles Chart.

The following year, she reached #4 in the Billboard Hot Latin Songs chart with "Algo Está Cambiando".

In 2006, she released the critically acclaimed Grammy Award-winning Limón y Sal for Best Latin Pop Album, which spanned the hits "Me Voy" and "Eres Para Mí".

In 2008, her first live album, MTV Unplugged, peaked at #162 on the Billboard 200 chart.

In 2010, she released her fifth studio release entitled "Otra Cosa" a week achieved a gold record for high sales and as a first single launches "Bien o Mal."