Dr. Julius No is a fictional character and the main antagonist in the 1958 James Bond novel and its 1962 film adaptation Dr. No, the first of the series, in which he was portrayed by Joseph Wiseman.

Later he was smuggled to the United States and settled in New York City, where he became a clerk and eventually Treasurer for a Tong in America, called the "Hip-Sings".

The workers are brutally supervised by Jamaican "Chigroes" (a portmanteau of "Chinese" and "Negroes", referring to their mixed ancestry), however they are paid good wages and given decent accommodations.

No, with aid from the Soviets, sabotages the nearby tests of American missiles by jamming their signals and making them land and explode on a different target than that planned.

No also admits there is more at play than the shopworn East-West rivalry; his intent is to create enmity between the USSR and USA in an attempt to make the Cold War hot.

When Bond is sent to investigate the murder of two British agents and any possible connection with recent rocket disasters, No orders several attempts on 007's life.

No fails in his own attempts to kill Bond; first, inadvertently, by locking him in a ventilation shaft, which is variously heated and filled with water; and then, deliberately, by beating him with his metal hands.

In the Daily Express James Bond comic-strip series by Yaroslav Horak and Jim Lawrence, Dr. No reappears in the story-line Hot-Shot, published between January 16, 1976 - June 1, 1976.

In it, Dr. No had survived his previous encounter with James Bond and has remerged as a wealthy Indian businessman named Mr. Huliraya, who serves as the main antagonist of the story.

Dr. No made several appearances in the cartoon series James Bond Jr.. His skin, however, was rendered bright green similar to the Mandarin in Iron Man possibly due to the chemicals he was exposed to in the film.

Julius No also appeared in the video game GoldenEye: Rogue Agent (almost-completely unrelated, especially in the meaning of the title, to the 1995 film), voiced by Carlos Alazraqui.

Despite his death in both the book and film, he appears alongside fellow enemies Ernst Stavro Blofeld, Auric Goldfinger, Francisco Scaramanga and Xenia Onatopp.

In the game, Xenia Onatopp works for No and he seems to possess a considerable army of well-equipped henchmen as well as numerous tanks and helicopter gunships that resemble V-22 Ospreys.

During the 1981 Ontario general election Progressive Conservative Premier Bill Davis mocked the Liberal leader Dr. Stuart Smith and his critical attitude towards the government by calling him "Dr. No".

[4] Similarly, American Republican politician and physician Tom Coburn was also known as "Dr. No" for his frequent opposition to legislation in the United States Congress, particularly bills which would increase federal spending.