Previously known as Junipero Serra High School, it was named for Junípero Serra, a Spanish missionary who founded Mission San Diego and other settlements in what is now California.

Following the murder of George Floyd in 2020, students started a petition to change the mascot from a conquistador, a symbol they said represented Spanish colonialism and its impact on the indigenous population.

[3][5] In the 1999-2000 season, the Boys Varsity Basketball won their first Section 2 Championship in school history and their third straight Eastern League Title.

In the 2011-2012 season, the girls' Basketball team won San Diego CIF by defeating West Hills High School.

Varsity Girls Soccer also won a CIF Div.