Due to her rotund figure, Gittelson was often cast as a love interest who often intimidated her husband or boyfriend.

Modern viewers will recognize Gittelson in her appearances in several early Three Stooges films such as Slippery Silks, Dizzy Doctors, Horses' Collars and The Sitter Downers.

Perhaps her most famous role was as Minnie in the Stooge film False Alarms, in which she played the large and man-hungry lady pursuing the affections of a reluctant Curly Howard.

Gittelson also appeared in many non-Stooges films, usually in minor roles and seldom credited.

Feature films in which she played character parts include King Kong (1933),[2] Mark of the Vampire (1935),[3] and Mr. Smith Goes to Washington (1939).