Vasquez worked with DJ and pop remixer/producer Shep Pettibone, and together they co-produced and edited numerous singles from artists like Madonna, Whitney Houston, Janet Jackson, MC Hammer, Prince, Pet Shop Boys and others.
[5] Major record labels began soliciting Vasquez to produce club-friendly remixes for their top singers using his personal beat-driven house style.
Due to a rise in demand from these labels, many singer and musicians like C+C Music Factory, David Morales, Björk, Marilyn Manson, and Madonna were known to frequent his Sunday morning events.
Vasquez held shorter-lived residencies at the various clubs in New York including, Exit Nightclub, the highest capacity club space in New York City where he called the Saturday to Sunday sets "Earth," Discothèque, Sound Factory (so-named by Richard Grant who retained legal rights to the name) and opened in a new space located in Hell's Kitchen section of Manhattan.
In addition to his work as a DJ and remixer, he has co-produced albums for John Mellencamp, For Real, Lisa Lisa, and Cyndi Lauper as well as individual LP tracks for Madonna, Cher, Wild Orchid, and Kristine W.[4] Vasquez, along with his former record label Junior Vasquez Music, is also known for introducing new artists, including many crossover singers, to dance/pop music scene, including Vernessa Mitchell, Jason Walker, Casey Stratton, Quentin Elias, Vivian Green, and Sam Harris.