He has previously played in MLB for the Texas Rangers, Oakland Athletics, San Diego Padres, and Colorado Rockies.

Profar was born in Willemstad and has been involved in organized baseball from a young age, representing Curaçao at the Little League World Series in 2004 and 2005.

He was called up to the major leagues in 2012 and received partial playing time in his first two seasons as a utility player.

After suffering a shoulder injury, Profar missed two full seasons and did not rejoin the Rangers until mid-2016 when he filled an active roster vacancy.

Upon arriving in San Diego, Profar was transitioned from a utility infielder to an outfielder, primarily playing in left field.

[11] On August 31, 2012, Profar was called up to the Rangers as major league rosters expanded and as a possible postseason addition.

On May 22, the Rangers organization announced Profar had reinjured his shoulder, and as a result missed the entire 2014 season.

[19] After missing a total of two seasons due to the shoulder injury, Profar was optioned to the team's Triple-A affiliate Round Rock Express on March 21, 2016.

On May 27, 2016, the Rangers called Profar up to the majors as a replacement for second baseman Rougned Odor, who was suspended by MLB for seven games for punching the Toronto Blue Jays' José Bautista.

Profar was named the 2018 Richard Durrett Hardest Working Man Award winner by the DFW chapter of the BBWAA.

[25][26] On December 21, 2018, the Rangers traded Profar to the Oakland Athletics in a three-team deal in which the Rangers acquired Brock Burke, Kyle Bird, Yoel Espinal, Eli White, and $750,000 of international signing bonus pool space and the Tampa Bay Rays acquired Emilio Pagan, Rollie Lacy, and a competitive balance pick in the 2019 MLB draft.

[27] The Athletics played Profar almost exclusively at second base to fill the void left by free agent Jed Lowrie.

After struggling on defense and to keep his batting average above .200, Profar was relegated to a platoon role when the Athletics called up Corban Joseph.

[28] On December 2, 2019, the Athletics traded Profar to the San Diego Padres in exchange for Austin Allen and a player to be named later or cash considerations.

[34] Following a collision with teammate CJ Abrams on July 7, 2022, Profar collapsed while walking off the field and was placed on the seven day injured list under the concussion protocol.

In the bottom of the inning, Profar singled before teammate Manny Machado hit a game winning home run.

[40] After four games for the Triple-A El Paso Chihuahuas, the Padres selected Profar's contract on September 8, adding him to the major league roster.