After the success of the Righteous Brothers' first single with Phil Spector, "You've Lost That Lovin' Feelin'", the writers of the song Barry Mann and Cynthia Weil then wrote "(You're My) Soul and Inspiration" for them.

[2] The Righteous Brothers released their version as a single in April 1965 as the follow-up to "You've Lost That Lovin' Feelin'".

Their second release on the Philles label, the single was another big hit, making the top ten of the Billboard Hot 100, reaching number nine.

Billboard described the song as "exciting, dramatic, emotion filled production performances by the "Lovin' Feeling" boys" which "can't miss.

"[3] The song was covered by the American rock band the Beach Boys and released on their 1976 album 15 Big Ones.