In the arc, alien invaders, working through a human-seeming agent known as the "Advance Man", use Hector Hammond, a telepathic supervillain, to cause the world to forget the existence of the Justice League of America.

When Hammond discovered the Advance Man's true motives, he attempted to reverse the process but was only able to transmit the partial phrase "Justice League of A--" before being incapacitated by the alien emissary.

He used the Justice League of Amazons to remove the loggers from the area so that he would be able to find an unknown spider that carried a virus capable of "exterminating the human surplus".

Unlike the other divisions, this team contains no obvious connecting theme:[4] The Justice League of Arkham was a team of Batman supporting characters: After learning of the Advance Man's plan to release a toxic gas that reacts with water to kill all life forms that come in contact with it in Gotham City, Batman freed The Joker from the Slab.

He also freed Riddler, Poison Ivy, and Ventriloquist from Arkham Asylum so that they could aid him in stopping the Advance Man.

The Justice League of Arkham broke into the processing plant in which the Advance Man was planning to release the toxic gas and captured him.

The Advance Man's large metal structures that he had created during the "Justice League of Atlantis" became active, and they started to transform people who had the correct DNA sequence into monsters.

The Justice League of Aliens fought several of the "monsters", but they were unable to prevent Plura from overtaking any of those remaining.