He is also known for his television appearances as Warren Cheswick in the NBC comedy-drama series Ed (2000–2004), Kevin Murphy in the Netflix original animated sitcom F Is for Family (2015–2021), and Nathan Bratt in the Disney+ series Goosebumps (2023), for which he was nominated for the Children's and Family Emmy Award for Outstanding Lead Performer.

[10] Long's film credits include Idiocracy, Waiting..., Jeepers Creepers, DodgeBall: A True Underdog Story, The Break-Up, Crossroads, Galaxy Quest, Dreamland and Live Free or Die Hard.

In 2007, he co-starred with Bruce Willis as a white-hat hacker in Live Free or Die Hard[13] and had a role in the comedy The Sasquatch Gang.

"[14] Long also had a small role in the comedy film Zack and Miri Make a Porno (2008) as Brandon St. Randy, a gay porn star.

[16] On August 16, 2010, he co-hosted WWE Raw with Going the Distance co-stars Charlie Day and Jason Sudeikis at the Staples Center in Los Angeles.

[19] In 2020, he appeared in the reality television series Celebrity Watch Party alongside his younger brother Christian Long.

[24][25] During an episode of the podcast Armchair Expert with Dax Shepard, Long revealed that he was the victim of a drugging and abduction during the filming of Youth In Revolt while in Michigan.

According to Long, after an evening of drinking, he left with several local people who offered him marijuana that he believed was actually phencyclidine, more commonly known as PCP.

According to Long, they made reference to filming him while high on hard drugs and selling the footage to TMZ or another website dedicated to celebrity gossip.

He supported Barack Obama during the 2012 U.S. presidential election and was an outspoken critic of the Republican nominee Mitt Romney, describing him as a "modern-day Gordon Gekko".