[5][6] In 2011, Zackham produced and directed his screenplay, The Big Wedding, featuring Robert De Niro, Diane Keaton, Susan Sarandon, Katherine Heigl, Amanda Seyfried, Topher Grace and Robin Williams.
David Frankel directed the film for The Weinstein Company starring the Tony Award-winner James Corden, Julie Walters, Colm Meaney, Mackenzie Crook and Alexandra Roach.
[11] The 2018 film starred Jennifer Lopez, along with Leah Remini, Annaleigh Ashford, Vanessa Hudgens, Dan Bucatinsky, Freddie Stroma, Milo Ventimiglia, Treat Williams and Charlyne Yi.
Zackham is the creator and executive producer of the FX drama series Lights Out, about a former heavyweight champion facing bankruptcy and Alzheimer's disease.
[12] He wrote Riverside, a 2007 television pilot, a coming of age semi-autobiographical drama about five men and a girl in their late 20s who have been friends since childhood and who struggle to maintain their tight-knit group in the face of adulthood.