She has also acted in the films Not Fade Away (2012), Frances Ha (2013), A Midsummer Night's Dream (2017), and Luckiest Girl Alive (2022) Born in New York City and raised in Colorado,[4] Lupe is a 2007 graduate of the Denver School of the Arts theater program and a 2011 graduate of the Juilliard School in New York City.

She played Flue in the 2017 film adaptation A Midsummer Night's Dream directed by Casey Wilder Mott.

She also starred alongside Jimmi Simpson in off-Broadway play Empathitrax written by Ana Nogueira.

[6] Elisabeth Vincentelli of The New York Times praised Lupe's performance describing it as "appropriately fidgety [and] raw-nerved".

She then had a leading role as Nell Rutherford opposite Mila Kunis in the film Luckiest Girl Alive (2022).