[6] In the August 2022 Republican primary election, Wadsack defeated incumbent Vince Leach, the senate president pro tempore.

[4] The Tucson police records did reflect that Wadsack had been taunted by one Texas man who was charged with misdemeanor hate crime and disorderly conduct.

[4] A state judge rejected the effort to remove Wadsack from the ballot, saying that the circumstances were "suspicious" but that the petitioners had not proven by "clear and convincing evidence" that she was not an LD 17 resident at the time of the primary.

"[12] In March 2023, Wadsack and other Freedom Caucus members denounced proposals to adopt ranked-choice voting in Arizona[11] and sponsored legislation to preemptively ban it in the state.

[13] She attracted attention for introducing legislation (SB 1700) to give parents the power to ask schools to ban books they deem inappropriate.

[16] Wadsack's bill was defeated after two Republican senators representing Districts with charter cities joined with Democrats to vote against it.

[17][19] Wadsack claimed that the State Bar of Arizona had threatened lawyers with disbarment if they represented litigants challenging COVID-19-related mandates and restrictions.

They said Wadsack's proposal would reduce capacity for students with visual and auditory impairments and fundamentally alter the school's curriculum, which is geared toward instruction in Braille and American sign language.

[22][21] Wadsack rejected these criticisms, but withdrew her bill in favor of a measure to create an ad hoc committee to study schools.

In response to her comments, the Arizona Fraternal Order of Police retracted their endorsement of Wadsack in the 2024 Republican primary race.