His first post was in the household of the Khedive of Egypt, Abbas I, at that time was only nominally dependent to the central Ottoman power in Constantinople.

As a neo-Tanzimatist, Kâmil Pasha petitioned the sultan to put responsible governance back in the hands of the Sublime Porte.

After the shuttering of parliament in summer 1912 by the Savior Officers, he became head of the Council of State in Muhtar Pasha's Great Cabinet.

In January 1913, Kâmil's government decided to accept severe peace conditions including massive territorial losses.

That day, Enver Bey, one of the CUP's military leaders, burst with some of his associates into the Sublime Porte while the cabinet was in session.

The ex-Grand Vizier (who probably was in danger of life) was invited by his British friend Lord Kitchener to stay with him in Cairo.

After three months in Egypt, Mehmed Kâmil Pasha decided to wait for favourable turn of events in his native Cyprus, now under British occupation.

Djemal Pasha, then the CUP prefect of the capital Constantinople, indicated to Kâmil's family that they had to leave the Ottoman Empire or he too would be arrested.

On 14 November 1913, while full of plans for revisiting England in 1914, Kâmil Pasha suddenly died of syncope and was buried in the court of the Arab Ahmet Mosque.

Sir Ronald Storrs, British Governor of Cyprus from 1926 to 1932, erected a memorial to be raised over Kâmil Pasha's grave.