[4] Soon after, she started work at the Egyptology and Archaeology Department of the Berlin State Museums, but she and her father were dismissed from their posts when it emerged that her mother was Jewish.

[6] In 1938, while at Oxford as a senior member of Somerville College, she met a fellow Egyptologist and research student, J. Gwyn Griffiths.

During the Second World War, Bosse-Griffiths and her husband set up the Cadwgan Circle from their home in Pentre, an avant-garde literary and intellectual group, whose members included Pennar Davies and Rhydwen Williams.

Bosse-Griffiths became a member of Swansea Museum, where she became Keeper of Archaeology, a role she undertook for 25 years, curating the collections almost to the day she died.

[4] She helped to bring Sir Henry Wellcome's Egyptian collection out of storage and into the Department of Classics at Swansea, where Bosse-Griffiths spent the next twenty years researching its 5,000 items.

Bosse-Griffiths was a published author writing in Welsh on German pacifist movements in Mudiadau Heddwch yn yr Almaen (1942).

Bosse-Griffiths' literary output of short stories and novels included Anesmwyth Hoen (1941), Fy Chwaer Efa a Storïau Eraill (1944), Mae'r Galon wrth y Llyw (1957; reprinted with a new introduction in 2016 by Honno Welsh Women's Classics), and Cariadau (1995), and two travel books, Trem ar Rwsia a Berlin (1962), and Tywysennau o'r Aifft (1970).