It is served by Rhine-Ruhr S-Bahn and regional services.

Cologne-Ehrenfeld is a scheduled stop for all regional services passing through it.

It is also served by the NRW-Express (RE1), Rhein-Erft-Express (RE8), Rhein-Sieg-Express (RE9), Rhein-Erft-Bahn (RB27) and Erft-Bahn (RB38), all running hourly.

This station offers connections on three Cologne Stadtbahn lines.

Köln-Ehrenfeld station was built with the construction of the first section of the Cologne–Aachen high-speed railway in 1839.