Superintendent Johann G. Weiß opened a private school for girls on Brodbänkenstraße in Kneiphof in 1811, but it was acquired by the city government six years later.
At that time, the school was relocated to a former boarding house for the poor on Danziger Keller in Altstadt, near Königsberg Castle.
[1] The school moved to a new building on Landhofmeisterstraße between Sackheim and Neue Sorge in 1901 and was renamed the Königin-Luise-Schule, after Queen Louise of Prussia (1776–1810).
In 1913, the Oberlyzeum and Frauenschule separated from the Königin-Luise-Schule and formed a new institution for the training of female teachers on Friedrichstraße.
It ceased its role as a German gymnasium in 1945 as a result of World War II and the evacuation and ethnic cleansing of East Prussia.