Kühkopf-Knoblochsaue is a Naturschutzgebiet (nature reserve) of European standard, located in the Groß-Gerau district, Germany.

It is the largest nature reserve in Hesse, part of the Hessian Ried between the river Rhine and the Hessische Bergstraße.

Until the beginning of the 17th century, the Kühkopf was a hunting area for noble families, also for farming from single estates (Hofgüter).

[2] On 7 december 1631, Gustavus Adolphus of Sweden and his army crossed the Rhine during the Thirty Years' War, memorialized by the Schwedensäule [de] monument[3] in the Knoblochsaue.

[4] In 1828/29, directed by Großherzoglicher Darmstädter Wasserbaudirektor Claus Kröncke [de], a shortcut of the river (Rhein-Durchstich) shortened the passage for ships.