[4][5] Tatlıtuğ has established himself as a leading actor of Turkey with roles in several of the highly successful television series, that includes Menekşe ile Halil (2007–2008), Aşk-ı Memnu (2008–2010), Kuzey Güney (2011–2013) and Cesur ve Güzel (2016–2017), all of which garnered him critical acclaim and international recognition,[6] portraying researcher Arman in the Netflix original series Into the Night (2021) and Yakamoz S-245 (2022).

[14] He has said that he was born and raised in Adana and that his family has had a bakery business in the city for more than a hundred years.

Tatlıtuğ played the poet Muzaffer Tayyip Uslu in the drama film Kelebeğin Rüyası with Farah Zeynep Abdullah.

He had guest role in fantasy series Acemi Cadı of Turkish version "Sabrina Teenage Witch" with Merve Boluğur for second time.

[23] He has also starred in other shows such as Menekşe ile Halil, where he played alongside of Sedef Avcı.

He won two Golden Butterfly Awards for Best Actor in a Leading Role for his performance in Aşk-ı Memnu and "Kuzey ve Güney".