The highway travels northeast through rural farmlands parallel to the Union Pacific Railroad track.

K-153 begins to travel north with the McPherson Airport to the west and an industrial area to the east, then enters the McPherson city limits just north of Iron Horse Road (Refinery Road).

The roadway continues north to Kiowa Road and enters into a more commercial area.

The highway then crosses over Bull Creek before reaching its northern terminus at US-56 (West Kansas Avenue).

[7] All but 1.268 miles (2 km) of K-153's alignment is maintained by the Kansas Department of Transportation (KDOT).

[8] KDOT tracks the traffic levels on its highways, and in 2020, they determined that on average the traffic varied from 2,740 vehicles per day south of K-153 Spur to 6,670 vehicles per day north of K-153 Spur.

The northern terminus (US-56) closely follows the former National Old Trails Road, which ran from Baltimore and Washington D.C. west to Los Angeles;[10] and Old Santa Fe Trail, which ran from Franklin to Santa Fe.