In 1959, she acted with Kann Thirandhathu starring Mynavathi under the direction of K. V. Srinivasan produced by Narayanan Companies and she was the onscreen pair for A. Karunanidhi.

She made her acting debut as heroine with Konjum Kumari starring R. S. Manohar and Manorama under the direction of G. Viswanathan and produced by Modern Theatres in 1963.

[3] Indira was the onscreen pair for M. N. Nambiar in MGR's Petralthan Pillaiya (1966), Gemini Ganesan in Sumaithaangi (1962) and M. R. Radha in Hello Mister Zamindar (1965).

[7] On 16 March 2017, Indira Devi was admitted to hospital in Chennai for respiratory problems and died following a Cardiac arrest.

A number of Tamil film celebrities including Secretary Vishal, Vice-president Ponvannan, and General council members Udhaya and Hemachander from Nadigar Sangam visited her place and paid their obeisance.