Known for his studies in the field of bioinformatics, Sekar heads the Laboratory for Structural Biology and Bio-computing at IISc.
During this period, he has held various positions including those of a principal research scientist (2004–10) and an associate professor of Computational and Data Sciences (CDS) department.
He holds the position of a professor of CDS department since 2016[2] and heads the Laboratory for Structural Biology and Bio-computing.
[3] Sekar's research in bioinformatics covered the fields of protein crystallography, crystallographic and internet computing as well as the development of value added knowledge bases and algorithms.
[7] He has delivered keynote or plenary speeches at international seminars and conferences[8][9] and has mentored many doctoral and post-doctoral scholars.