It carried its schedule of dramas, comedies, news, sports, soap operas, game shows and big band broadcasts during the "Golden Age of Radio."

With the 1941 enactment of the North American Regional Broadcasting Agreement (NARBA), WDSU moved to 1280 kHz.

In the early 1990s, WQUE tried an all-sports format that included broadcasts of the New Orleans Saints, but it didn't last long.

Hornets radio color analyst Gerry Vaillancourt hosted a popular afternoon sports talk call-in show from May 2004—December 2006.

The station's final sports-era legal ID was an homage both to the station's small, but loyal following, and to the Jim Rome Show; it contained a frequent Rome Show sign-off clip ("I think what I'm supposed to say is, 'Thank you.

[5] On September 4, 2012, the station became an affiliate of ESPN Deportes Radio, as a Spanish-language sports outlet.

On June 29, 2020, fifteen iHeart stations in markets with large black populations, including WODT New Orleans, began stunting.

The speeches of prominent African Americans were aired, interspersed with messages such as "Our Voices Will Be Heard" and "Our Side of the Story is About to be Told,."