The three stations share studios on Southeast 11th Avenue and South Fillmore Street in downtown Amarillo; KAMR-TV's transmitter is located on Dumas Drive (US 87–287) and Reclamation Plant Road in rural unincorporated Potter County.

On September 5, 1951, the Plains Radio Broadcasting Company—a subsidiary of Globe News Publishing Co. (owned by landowner and oilman Roy N. Whittenburg and civic leader Samuel "S.

[2][3] The FCC awarded the license and permit for channel 4 to Plains Radio Broadcasting on October 8, 1952; the group subsequently requested and received approval to assign KGNC-TV (for Globe-News Company) as the television station's call letters.

The operations of KGNC-TV were originally located at a facility on North Polk Street and Northeast 24th Avenue in northeastern Amarillo, which it shared with KGNC radio.

Each of these telecasts featured an NFC or AFC team of interest to significant cohorts of KAMR's viewing area (particularly, the Dallas Cowboys and the Denver Broncos).

[20][21][22][23] On February 25, 2013, the over-the-air signals of KAMR, KCIT and KCPN were knocked off the air for more than 18 hours as a result of electricity fluctuations that shut off cooling pumps on the stations' transmitter tower off of US 287 during a major blizzard that crippled much of the Texas Panhandle.

[24] KAMR-TV currently broadcasts the majority of the NBC schedule, although the station currently does not clear most of NBC's overnight programming (preempting its weekend lifestyle lineup outright and carrying Early Today as a single half-hour broadcast instead of offering most of its customary overnight loop), preferring to carry infomercials and some syndicated programming in the designated time period (particularly on Tuesday through Saturday mornings after Late Night with Seth Meyers).

Through the shared services agreement with KCIT, the station may also simulcast long-form severe weather coverage on channel 14 in the event that a tornado warning is issued for any county in its viewing area within the Texas and Oklahoma Panhandles as well as Eastern New Mexico.

)[26] Following their respective sales to Quorum and Mission Broadcasting and the formation of the SSA between the two stations, on March 11, 2001, KAMR began producing a half-hour newscast at 9 p.m. through a news share agreement with Fox affiliate KCIT.

Weeknight anchors Jay Ricci and Paige Cook both quit after Nexstar management asked them to accept a reduction in their salaries in contract renewal negotiations.

KAMR-TV covers a large portion of northern Texas, the Oklahoma Panhandle and northeastern New Mexico through many translators that distribute its programming beyond the 65.6-mile-wide (105.6 km) range of its broadcast signal.