[10] Under Engles, KBSI picked up the first season of NYPD Blue when ABC affiliate WSIL-TV refused to air the show.

[13] From 2006 to September 30, 2010, NBC affiliate WPSD-TV (owned by the Paxton Media Group) produced a nightly prime time newscast for KBSI through a news share agreement.

That newscast, produced by CBS affiliate KFVS-TV, focused on news from southeastern Missouri and was eventually canceled on July 29, 2007.

The news and weather anchors are based in Lincoln while the reporters work out of the KBSI studios in Cape Girardeau.

The station's signal is multiplexed: KBSI shut down its analog signal, over UHF channel 23, on February 17, 2009, the original target date on which full-power television stations in the United States were to transition from analog to digital broadcasts under federal mandate (which was later pushed back to June 12, 2009).