As newcomers to the competition, the 2000–01 season, led by coach Željko Lukajić, they reached the finals, where they were stopped by Spain's Unicaja Málaga, which was headed by Božidar Maljković.

That same year, the team's quality was confirmed with placement at the National Cup final tournament, which was organized in Vršac for the first time, at the opening of the Millennium Centar.

Reaching the Eurocup Final Eight in Turin was a great success for Serbian basketball, especially as Hemofarm had the youngest team in the whole competition.

In the first match of the tournament in Italy the "Pharmacists" have made another surprise, defeating favored Dynamo Moscow, but are uncertain in the semifinals in a precarious lost to Lietuvos rytas, which went on to win the competition.

In the middle of the 2011–12 season, Hemofarm Group stopped to finance the club after 20 years because of the financial crisis in the company.

A few days after the end of the 2023/2024 season, on April 16, the club announced that it had signed a title sponsorship agreement with Meridianbet.

The club has had several denominations through the years due to its sponsorship: Note: Flags indicate national team eligibility at FIBA-sanctioned events.