It is owned by Gray Media alongside low-power Gulf Coast Sports & Entertainment Network affiliate KCWL-LD (channel 40, also licensed to Monroe).

The station also operates a low-powered translator, K20OC-D in El Dorado, which rebroadcasts KNOE-TV's digital signal in high definition.

James A. Noe Sr., former governor of Louisiana, owned the television station as well as KNOE radio (AM 540, now KMLB, and FM 101.9, now KMVX).

In 1969, KNOE installed a translator station on channel 18, K18AB, atop the First National Bank Building in El Dorado to better serve viewers in that area.

The deal also included the acquisition of Parker Broadcasting, owner of ABC affiliate KAQY, which KNOE-TV had operated under a local marketing agreement since 2008.

On December 30, 2023, KNOE-TV parent company Gray Television announced it had reached an agreement with the New Orleans Pelicans to air 10 games on the station during the 2023–24 season.

It has won numerous state, regional and national journalism awards, including the 2008 Alfred I. duPont-Columbia University Award for News Director Taylor Henry's investigative series on rogue members of the Louisiana National Guard who looted stores they were deployed to protect during Katrina.

On January 17, 2011, KNOE-TV began broadcasting local newscasts and field reports in high definition, becoming the first station in the Ark-La-Miss region to do so.

The episode had all mention of KNOE-TV's CBS and ABC affiliations obscured on-set for copyright reasons, through virtual or physical means.