KPDX (channel 49) is a television station licensed to Vancouver, Washington, United States, serving the Portland, Oregon, area as an affiliate of MyNetworkTV.

The two stations share studios on NW Greenbrier Parkway in Beaverton; KPDX's transmitter is located in the Sylvan-Highlands section of Portland.

[4] The construction permit was granted by the Federal Communications Commission (FCC) on January 5, 1981, and took the KLRK call letters, representing Clark County.

[6] Camellia's entry in the Portland market was significant because it bought rights to $10 million of films and syndicated programs, which particularly harmed KECH.

[9] Camellia also soon acknowledged that a Washington-specific focus would limit the station's audience and appeal, and changed the call sign to KPDX, representing Portland's airport code.

Although it was well behind KPTV, one of the strongest independent stations in the country, KPDX more than held its own in its early years and received decent ratings.

The station relocated its studios to a new building located on NE Union Avenue (now Martin Luther King Jr. Boulevard) in Portland by 1989, by which point they had rebranded themselves as "Fox 49".

Meredith took advantage of the KPTV acquisition by moving the latter station from its older downtown studios and into the new modern facility built for KPDX in Beaverton.

Because Media General already owned CBS affiliate KOIN (channel 6) and Meredith owns KPTV and KPDX, the companies would have been be required to sell either KPTV or KOIN to comply with FCC ownership rules that forbid common ownership of two of the four highest-rated television stations in a given market in total day viewership, as well as recent changes to FCC ownership rules that restrict sharing agreements; KPDX was the only one of the three stations affected by the merger that could legally be acquired by Meredith Media General, as its total day viewership ranks below the top-four ratings threshold.

Up until Apple TV+'s acquisition of global Major League Soccer television rights in June 2022 (starting in the 2023 season), through a partnership with sister station KPTV, a select number of Portland Timbers matches aired on KPDX.

[20] In February 2025, KPDX will air matches from the Coachella Valley Invitational preseason tournament featuring the Timbers and Portland Thorns FC of the National Women's Soccer League.

On April 19, 2010, KPTV began producing a fifth hour of its weekday morning newscast Good Day Oregon for KPDX (running from 9 to 10 a.m.) called More Good Day Oregon, which featured various entertainment and lifestyles topics from a seasoned panel of experts; the program was cancelled in 2012 and was replaced by syndicated programming.

On September 29, 2014, KPDX expanded its evening news programming with the launch of an hour-long 9 p.m. newscast, resulting in KPTV producing three hours of news in prime time (two hours on channel 49, as well as the flagship hour-long 10 p.m. broadcast on channel 12); as a result, the station delayed MyNetworkTV programming later in the evening.

With the ATSC 3.0 transition, the KPDX subchannels moved to the KPTV and KGW multiplexes and were added to their dependent translator stations.