It is owned and operated by the Ion Media subsidiary of the E. W. Scripps Company, and maintains a transmitter near Missouri City, in unincorporated northeastern Fort Bend County.
The station first signed on the air on June 16, 1989, as KTFH (not to be confused with present-day UniMás owned-and-operated station KFTH-DT, channel 67); mainly airing home shopping programming, before becoming an over-the-air affiliate of Spanish-language network Galavisión (which is primarily distributed through cable, satellite television, and IPTV) in November of that year.
Paxson then dropped Galavisión and affiliated it with its Infomall Television Network (inTV) infomercial service on April 3, 1995;[3] its call letters were later changed to KPXB in early 1998.
On September 24, 2020, the Cincinnati-based E. W. Scripps Company announced it would purchase KPXB-TV's owner, Ion Media, for $2.65 billion, with financing from Berkshire Hathaway.
After the digital transition, KPXB moved its transmitter from east of Splendora to the Houston-area antenna farm near Missouri City.