It is owned and operated by the Ion Media subsidiary of the E. W. Scripps Company alongside NBC affiliate KJRH-TV (channel 2).
The station first signed on the air on July 3, 1997, as KGLB-TV; it originally carried programming from Paxson Communications' infomercial service, the Infomall Television Network (inTV).
On September 24, 2020, the Cincinnati-based E. W. Scripps Company announced that it would purchase Ion Media for $2.65 billion, with financing from Berkshire Hathaway.
KTPX airs the entire Ion schedule and since the repeal of the Main Studio Rule, it carries the network without any local content outside of an hourly on-screen station identification; the station is also not currently used by KJRH to carry preempted NBC and syndicated programming.
The station's signal is multiplexed: KTPX-TV shut down its analog signal, over UHF channel 44, on June 12, 2009, the official date on which full-power television stations in the United States transitioned from analog to digital broadcasts under federal mandate.