It starts from Dashte Barchi in Kabul and passes through Maidan Shar, Saydabad, Ghazni, and Qalat until it reaches Aino Mina in Kandahar.

In the 1980s, in addition to trucks and private vehicles, military convoys of the Soviet Union were often seen passing back and forth between Kabul and Kandahar.

The rebuilding project was overseen by the Louis Berger Group, with assistance in planning and design by Turkish and Indian engineers.

[14] The Dashte Barchi bus terminus provides transport services to the provinces of Maidan Wardak, Bamyan, Ghazni, Daikundi and Ghor.

[15] Another such terminal is in Aino Mina in Kandahar,[16] and yet another on the western end of that city which provides bus services to Lashkar Gah, Zaranj, Farah and Herat.

On May 8, 2016, a major vehicular crash killed at least 73 and injured over 50 people along the Kabul-Kandahar Highway in Moqor District of Ghazni Province.

[19] At least 38 persons died in September 2016 when a fuel tanker collided with a passenger bus in the Jildak area of Zabul Province.

[20] On December 18, 2024, a total of 50 people are killed and 76 others are injured in two separate crashes along the highway in Ghazni Province, including a collision between a passenger bus and an oil tanker.