[1] Nearby localities include Kafr Nabudah and al-Habit to the northwest, Khan Shaykhun to the northeast, Mork to the east, Suran to the southeast, al-Lataminah, Halfaya and Mahardah to the south, Tremseh to the southwest and Kirnaz and Hayalin.

[5] In the late Ottoman period, between the 18th-19th centuries, the residents of Kafr Zita, which at that time was one of the largest villages in the area north of the Orontes River, were regularly in arrears for tax payment and had to obtain financial assistance.

[7] The residents claimed ancestry from the Mawali tribe,[8] which had dominated the Syrian steppe until migrating to northwestern Syria in the late 18th century.

[11] On 20 December rebels claimed to have captured Kafr Zita and a string of other nearby towns during an offensive against government forces in the vicinity of Hama.

On 20 August 2019, the Syrian Observatory for Human Rights reported that the rebel and Islamic factions including jihadist group Hayat Tahrir al-Sham (HTS) had withdrawn from Kafr Zita in north Hama province.