It was established more than 50 years ago by Raesi Mengesha Seyoum, the then ruler of Tigray province as Shire Wildlife (citation required).

Kafta Sheraro National Park is specifically located in western Tigray, between Qafta, Humera, and Tahtay Adiabo.

[4] During a certain expedition to Kafta-Sheraro National Park from 26 March to 16 April 2009, more than 21,500 Demoiselle Cranes Anthropoides Virgo were recorded, or 9% of the world population of the species.

It appears to confirm that the Kafta-Sheraro area serves as a wintering site for the species and identifies this part of the Tekeze Valley as a wetland of international significance.

Other notable wildlife species include lion, leopard, caracal, aardvark, greater kudu, roan antelope, red-fronted gazelle, hyena, crocodile, cheetah, and red-necked ostrich.