She is the younger of two children born to the supermodel Cindy Crawford[6] and the businessman Rande Gerber.

[9] Her mother, who is of German, English, French, and Danish ancestry, is a Congregationalist Christian[10][11] and her father is an American Jew.

"[12][13][14] Through her mother, she is a descendant of English Puritan settler Thomas Trowbridge, who helped establish the Congregational Church in New Haven.

[17] Gerber made her acting debut at 15 in Sister Cities as the young version of Carolina.

[20] In 2016, Gerber was also part of the Marc Jacobs "Daisy" fragrance advertisement and beauty fall campaign.

[22] Gerber made her runway debut for Raf Simons's Calvin Klein Collection at 16 years old and walked for fashion houses such as Marc Jacobs, Burberry, Alexander Wang, Coach, Prada, Chanel, Fendi, Miu Miu, Max Mara, Givenchy, Bottega Veneta, Stella McCartney, Isabel Marrant, Alberta Ferretti, Loewe, Chloé, Sacai, Michael Kors, Moncler, JW.

Anderson, Longchamp, Tom Ford, Salvatore Ferragamo, Ports1961, Lanvin, Anna Sui, Moschino, Saint Laurent, Alexander McQueen, Valentino, and Versace, alongside her mother, during 2018 Spring Fashion Week.

[33] In 2020, Gerber starred in the Louis Vuitton "Twist bag" spring summer advertising campaign photographed by Craig McDean.

In 2023, Gerber covered the American and French editions of Elle[43] and starred in an advertising campaign for Alaïa.

[44] She also appeared in the teen sex comedy film Bottoms alongside Rachel Sennott and Ayo Edebiri.

[47] In 2024, Gerber appeared on the British Vogue for the March issue which featured 40 icons in the fashion industry.

On April 6, 2024, Gerber appeared in a cameo role in the Saturday Night Live sketch "Pilates".