He was inspired by the classical musicians Kumar Gandharva, Hridaynath Mangeshkar, Bhimsen Joshi, and the Qawwali singer Nusrat Fateh Ali Khan.

With his powerful voice and his unique style of music, Kher has established himself as one of the most popular playback singers of India.

[9] Even as a four year old, Kher displayed natural musical talent and would often impress friends and family by belting out songs with his prematurely powerful voice.

[16][17] In 2001, Kher left Delhi for Mumbai, the center of India's highly competitive music industry, as a professional singer.

For a while, Kher struggled, living in cheap hostels and doing whatever musical work he could find to make ends meet.

Kher is the only singer in India,[citation needed] who often includes a classical lyrics and folk language in his solo albums and films.

Most of his film or non-film albums include romantic tracks with a touch of classical music, lyrics and traditional languages.

[citation needed] He has given music score's for numerous movies like Chandni Chowk To China, Dasvidaniya, Sacred Evil, Sangini, Desi Kattey etc.

[25] By 2014, he had sung in more than 20 Indian languages including Malayalam, Tamil, Telugu, Kannada, Oriya, Bengali, Sindhi, Bhojpuri, Gujarati, Marathi, Punjabi, Konkani, Rajasthani etc.

He has composed and sung the title track of Star Plus's serial Diya Aur Baati Hum along with Shubha Mudgal.

He has also sung the title track of Colors serial "Udaan" along with the anthem for Swachh Bharat Abhiyan, the national campaign for cleaning India.

[citation needed] Kher has also sung a few non-filmy Nepali pop songs including "Phool Ko Thunga" and "Bolnai parcha bhanne K cha ra" from the album called Only Love in 2011.

He has not only performed for the south east Asian diaspora, but also for international audiences in festivals and venues such as GlobalFest at New York's Webster Hall, Kennedy Center (Washington D.C.), Stern Grove Festival (San Francisco), Celebrate Brooklyn, Santa Monica Pier Festival (LA), Fillmore Center (San Francisco), Hollywood Bowl (LA), Hammersmith Apollo (London), Symphony Hall (Birmingham), Massey Hall (Toronto).

[30] In 2007, he participated in a concert tour in North America entitled "The Incredibles", also starring Asha Bhosle, Sonu Nigam and Kunal Ganjawala.

[32] In 2012, as part of Kailasa's third Nepal tour, Kher performed at Dhaka in Bangladesh, Nairobi in Kenya, Zimbabwe and Congo, Karachi in Pakistan and Muscat in Oman.

[33] He has appeared in various television shows, including Wind of Change (Bangladesh) (Gaan Bangla),[34] Saregamapa Li'l Champs (Zee TV), Mission Ustaad (9X), Indian Idol 4 (Sony), IPL Rockstar (Colors) and Rock On (MTV).

[45] He lend his voice to the Clean India Mission theme song, ' Swachha Bharat Ka Irada Kar Liya Humne',[46] which is lyriced Prasoon Joshi.

Taking forward the Clean India Mission, Kher visited several places in PM's parliamentary constituency drawing praise from Narendra Modi.

"[47] Kher also did a viral video campaign called #KyaKisikoPadiHai along with Jose Covaco as a part of Swachh Bharat Mission.

[48] Kher was also invited by the PM to accompany him in his first USA tour, where they performed in the SAP center community reception at San Jose, California on 27 September'15.