[1][2] Between 2003 and 2005 O'Keefe filmed two guest appearances in the Seven Network television series All Saints.

[3] In 2005, O'Keeffe made his film debut aged fourteen in Swimming Upstream, starring as a Harold Jr.[4] O'Keeffe then secured a regular role Blue Water High as Guy Spender, after previously appearing in a guest role as another character called Ryan.

[5] In 2009, it was announced that O'Keeffe had joined the cast of Home and Away playing the role of Brendan Austin as part of the serial's new family.

O'Keeffe was working alongside his former Blue Water High colleague, Rebecca Breeds.

[7] ABC later picked up the rights to Resistance and went the programme went into pre-production in 2011, with a planned airdate of late 2012.