[3] In 2005, O'Keeffe made his film debut aged fourteen in Swimming Upstream, starring as a Harold Jr.[4] O'Keeffe then secured a regular role Blue Water High as Guy Spender, after previously appearing in a guest role as another character called Ryan.

[3] O'Keeffe said that he did not mind filming more than one role in the same series, because he felt the industry was "quite small".

[5] In 2009, it was announced that O'Keeffe had joined the cast of Home and Away playing the role of Brendan Austin as part of the serial's new family.

O'Keeffe was working alongside his former Blue Water High colleague, Rebecca Breeds.

[7] ABC later picked up the rights to Resistance and went the programme went into pre-production in 2011, with a planned airdate of late 2012.