Estonia became one of the largest donors of weapons for Ukraine per capita[8] and received over 40,000 Ukrainian refugees.

[10] In November 2021, Centre's Anneli Ott announced her resignation after criticism related to her not allowing herself to be vaccinated against COVID-19, citing disagreements with the Reform Party on restrictions.

Her resignation revealed deeper disagreements between the two coalition parties regarding COVID-19 restrictions and vaccination.

[11] On 2 June 2022, Kallas dismissed the seven ministers of the Centre Party after several weeks of deadlock, during which her coalition partner voted with the far-right EKRE opposition against an education bill.

[2][12] Continuing with a minority cabinet, the Reform Party called up the conservative Isamaa and the Social Democrats for talks on a possible new coalition.