On December 21, 2015, the club was officially named "Kalamazoo FC" as stated in an email by the team owner.

The first goal in Kalamazoo FC franchise history came in the thirty-second minute from Midfielder Jose Garcia to put the visiting team ahead 1–0.

The first victory in franchise history took place on May 22 against NPSL powerhouse side Detroit City FC in front of a crowd of 1,585 spectators.

The 2016 team featured Western Michigan University's Brandon Bye who would go on to be the 8th overall pick in the Major League Soccer SuperDraft to the New England Revolution.

Kalamazoo FC opened the 2017 season on the road at AFC Ann Arbor and suffered a 2–0 loss to the eventual division winner.

Along with a new coaching staff, the 2021 season saw KZFC switch to USL League 2 specifically being placed in the Great Lakes Division of the Central Conference.

After a couple pre-season friendlies, the club won their inaugural USL League 2 match versus South Bend Lions 1-0 thanks to a late volley from midfielder Daire O-Riordan.

Early season results would send KZFC to the top of the table with outside pressure coming from Cincinnati Kings Hammer and Flint City Bucks.

Offensive efforts led by Cyrus Harmon, Enrique Banuelos and Daire O'Riordan would complement a stout defensive unit an continue the club's rise through the power rankings throughout the summer, earning a spot as high as number 12 in the nation according to USL League 2.

In their final match of the season at Fort Wayne FC, it would take a couple second-half tallies from forward Enrique Banuelos to secure the victory and henceforth the division title.