[3] Sitake played college football as a fullback for the BYU Cougars under coach LaVell Edwards, and graduated in 2000.
After returning and redshirting in 1997, Sitake was a three-year starter at fullback for BYU from 1998 to 2000 under hall of fame coach LaVell Edwards.
[5] On December 23, 2014, OSU announced Sitake's hiring as the team's new defensive coordinator and assistant head coach.
[7] On September 3, 2016, Sitake's head coaching career began with BYU facing Arizona in the Cactus Kickoff in University of Phoenix Stadium in Glendale, AZ.
Expectations were high for BYU heading into the 2017 season, despite the loss of many graduating seniors, including starting quarterback Taysom Hill and running back Jamaal Williams.
The loss of offensive production proved to be detrimental, as the Cougars had their worst season in over 50 years, starting 1–7 before slogging to a 4–9 finish.
Sitake benched starting quarterback Tanner Mangum in favor of true freshman Zach Wilson.
BYU initially had success with upset wins over Power Five programs such as Tennessee and a ranked USC team, but inconsistency returned.
2019 was defined by the depth at the quarterback position, though, as backups Jaren Hall and Baylor Romney both led BYU to wins late in the season to help get the team to the Hawai'i Bowl against the University of Hawaiʻi.
The offseason began with a highly anticipated competition for the starting quarterback position between Wilson, Hall, and Romney.
Holmoe gradually re-built the season by adding several teams on short notice, allowing the Cougars to play as many games as possible.
Wilson won back the starting job, and successfully Sitake guided the team through the revamped schedule.
In his sixth season as head coach at BYU, Sitake replaced Wilson with starting quarterback Jaren Hall.
However, BYU won the game 26–17 and ended the Utes' 9-win streak against the Cougars with a strong defensive and offensive dominance.