Kalotina (Bulgarian: Калотина [kɐˈɫɔtinɐ]) is a village in the Dragoman Municipality, Sofia Province, in westernmost central Bulgaria.

The village is located at the border with Serbia, 55 km to the northwest of the capital Sofia, on the main highway and railway between Western Europe and Asia.

The place is known for the Kalotina-Gradinje border checkpoint, one of Bulgaria's busiest and best known due to the proximity to Sofia.

The Nishava River, a tributary of the South Morava, flows nearby.

Kalotina's name is the feminine form of an adjective derived from the personal name Kalota (Калота); it is an ellipse, as no noun is part of the name.