Kals am Großglockner is a municipality in the district of Lienz in the exclave of East Tirol in the Austrian state of Tyrol.

Kals is located in northern East Tirol, near the border to Salzburg and Carinthia.

Kals is divided into the following Katastralgemeinden: Unterpeischlach, Oberpeischlach, Staniska, Arnig, Lesach, Lana, Ködnitz, Glor-Berg, Großdorf, Unterburg, and Burg.

Kals was the starting point for the first ascent of Großglockner in 1853.

Kals is a large tourist center, with an average of about 100,000 visits in the summer.