[citation needed] A Tamilian from Mumbai, Kalyani has a degree in English literature and worked as a teacher and consultant.
In the same year, she played Imran Khan's sister-in-law in Dharma Productions' Gori Tere Pyaar Mein (2013).
[citation needed] Atlee signed her to play a doctor in Theri (2016) after seeing her performance in Pisaasu.
[citation needed] Kalyani made her Telugu film debut with Dictator (2016) and has acted in Mahanubhavudu (2017), Vijetha (2018), Dear Comrade (2019) amongst others.
[10] She is one of the founding members of a Mumbai-based theatre production house Clean Slate Creations along with her husband Balakrishnan Natarajan, who is also an actor in Hindi cinema.