Kamakwie is a town in the North West Province of Sierra Leone.

Since 2017 Kamakwie is the Capital of the Karene District in Chiefdom Sella Limba.

The main economic activities of Kamakwie are trading and farming.

Kamakwie is a religiously diverse town as it is home to a large population of both Muslims and Christians.

They help provide basis needs and supplies, livelihood empowerment skills programs, and shelter in the form of orphanage for homeless children.