Prior to entering politics, Khera attended York University where she earned an Honours Bachelor of Science in Nursing.

[2][3] Khera was nominated as the Liberal candidate in Brampton West in December 2014, and won the seat in the federal election in the following October.

[4][5][6] When first elected in 2015, Khera was the youngest Liberal MP in the House, and the second-youngest overall behind Pierre-Luc Dusseault of the New Democratic Party (NDP) .

[12] Her mandate was marked by the government’s restoration of the age of eligibility for retirement back to 65, an increase of the Guaranteed Income Supplement (GIS), which has helped over 900,000 seniors, and has lifted 45,000 of them out of poverty, the enhancement of the Canada Pension Plan (CPP), and a 10 per cent increase of Old Age Security (OAS) pensions for seniors over 75.

[14] On June 8, 2024, Khera announced the launch of the federal government's new Anti-Racism Strategy, a $110.4 million investment aimed at driving action in employment, justice and law enforcement, housing, healthcare and immigration systems.