[4] Kameko made his racecourse debut in a maiden race over seven furlongs at Sandown Park on 25 July when he started at odds of 15/2 in an eight-runner field.

After racing in fourth place he took the lead approaching the final furlong and held off a late challenge from the outsider It's Good To Laugh to win by half a length.

Murphy positioned the colt just behind the leaders before going to the front in the last quarter mile but he was caught near the finish and beaten a neck by the Aidan O'Brien-trained outsider Royal Dornoch.

The Group 1 Vertem Futurity Trophy at Doncaster Racecourse on 26 October attracted an unusual five-day entry of twelve, with Kameko matched against eleven colts from the O'Brien stable.

As a result of heavy rain at the already waterlogged Yorkshire track the race was abandoned and rescheduled to take place six days later on the synthetic Tapeta surface at Newcastle Racecourse, with entries being reopened.

In the new race Kameko started the 11/2 third favourite behind the unbeaten Kinross and Mogul, the winner of the Champions Juvenile Stakes and the best fancied of the five O'Brien runners.

[9] The flat racing season in England was disrupted by the COVID-19 Pandemic and the 2000 Guineas was run a month later than usual on 6 June over the Rowley mile at Newmarket.

Murphy settled his mount in mid division as Persuasion set the early pace from Juan Elcano, Starcat and Wichita.

Entering the last quarter mile Wichita went to the front with Pinatubo on his left and Military March to his right as Kameko looked to be trapped behind horses and unlikely to obtain a clear run.

In the final furlong Kameko forced his way between Wichaita and Military March to gain the advantage and despite hanging right towards the centre of the track he won by a neck.

[14] Later that month the colt was dropped back in distance and matched against older horses for the first time in the Sussex Stakes over one mile at Goodwood Racecourse.

He started well before settling behind the leaders but was repeatedly denied a clear run in the straight and finished fourth behind Mohaather, Circus Maximus and Siskin.

He raced towards the rear before moving into second place behind the front-running Ghaiyyath in the straight but faded in the final furlong and came home fourth of the five runners.

Kameko raced in fourth place as Benbatl set the pace but gained the advantage approaching the final furlong and kept on well to win by half a length from Regal Reality.

"[18] For his final race Kameko was sent to the United States for the Breeders' Cup Mile at Keeneland on 7 November and went off the 4/1 favourite but after tracking the leaders he faded in the closing stages and came home seventh of the fourteen runners, beaten 3+1⁄4 lengths by the upset winner Order of Australia.