He played in Major League Baseball (MLB) for the Texas Rangers, Milwaukee Brewers, Seattle Mariners, Chicago Cubs, and Atlanta Braves.

[1] Loe played college baseball at California State University, Northridge from 1999 to 2002, and was drafted by the Philadelphia Phillies in 1999 but did not sign.

He made his MLB debut with the Rangers on September 26, 2004, against the Seattle Mariners, working 2.2 scoreless innings of relief.

In late March 2008 he was considered one of three pitchers vying for one long relief spot with the team, along with Josh Rupe and Scott Feldman.

On December 18, 2009, Loe signed a minor league contract with the Milwaukee Brewers, which contained an invitation to spring training.

[5] After beginning the season with the AAA Nashville Sounds, Loe was called up to the big league roster by the Brewers on June 1, 2010.

After becoming a free agent following the season, Loe tested positive for a "drug of abuse" and was suspended for 50 games.

On March 3, 2016, Loe came out of retirement and signed a minor league contract with the Chicago White Sox.

Following his suspension, Loe made 13 appearances (12 starts) for the Triple–A Charlotte Knights and posted a 4.63 ERA with 40 strikeouts across 68 innings pitched.

Loe owned a 7-foot boa constrictor named Angel who he put up for adoption when he left the United States and moved to Japan for his job with the Fukuoka SoftBank Hawks in 2009.