Kamiōsaki (上大崎) is a district of Shinagawa, Tokyo, Japan.
The district is in the northern part of Shinagawa and borders Mita (Meguro-Mita) and Ebisuminami on the north, Shirokanedai on the east, Higashigotanda on the southeast, Nishigotanda on the southwest, and Meguro and Shimomeguro on the west.
Otherwise, most of Kamiōsaki is a quiet upscale residential district, notably with its 2-chōme and 3-chōme called Chōjamaru (長者丸) and Hanabusayama (花房山), respectively.
Shinagawa City Board of Education operates public elementary and junior high schools.
All of it is zoned to Hino Gakuen (日野学園) for junior high school.