Kamieskroon was founded in 1924, when the Dutch Reformed Church bought the land to relocate from Bowesdorp, 8 km to the north of the current location of the town.

The move was forced by a shortage of water and restricted space for the growth of the town.

Also located close to Kamieskroon is Boesmankop, a mountain that resembles a Boesman (Bushman or San) lying on his back.

Between 1969 and 2003 it was a military base housing two Armoured Squadrons equipped with Ratel-90 and four Companies of SA 9th Light Infantry Regiment.

Daytime temperatures commonly reach thirty-five degrees Celsius (95 °F) in summer while some frost may be experienced during clear winter nights.