Kamiiso Station (上磯駅, Kamiiso-eki) is a railway station on the South Hokkaido Railway Line in Hokuto, Hokkaido, Japan, operated by South Hokkaido Railway Company.

Kamiiso Station is served by the 37.8 km South Hokkaido Railway Line between Goryōkaku and Kikonai.

The station has two platforms serving three tracks.

Kamiiso Station on the Esashi Line opened on 15 September 1913.

[1] With the privatization of JNR on 1 April 1987, the station came under the control of JR Hokkaido.