Kamimizo Station (上溝駅, Kamimizo-eki) is a passenger railway station located in the city of Sagamihara, Kanagawa Prefecture, Japan, operated by the East Japan Railway Company (JR East).

Directly operated by the railway company, the station features a staffed ticket-service window.

Additional facilities include an elevator, an escalator, a multipurpose toilet, beverage vending machines, and public telephones.

Kanagawa Chuo Kotsu operates buses that stop at the station's six bus platforms.

On April 1, 1987, with the dissolution and privatization of the Japan National Railways, the station came under the operation of JR East.